MBS4381127 | NRF1

NRF1 | MBS4381127 | Mybiosource

Product Short Name: [NRF1]

Product Name Synonyme: [alpha pal; Alpha palindromic-binding protein; Alpha-pal; locus control region factor 1; NFE2 related factor 1; Nuclear respiratory factor 1 (NFR-1)]

Other Names: [nuclear respiratory factor 1 isoform 1; Nuclear respiratory factor 1; nuclear respiratory factor 1; nuclear respiratory factor 1; Alpha palindromic-binding protein]

Product Gene Name: [NRF1]

Product Gene Name Synonyme: [NFE2L1]

Other Gene Names: [NRF1; NRF1; ALPHA-PAL; NRF-1; Alpha-pal]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [NRF1/2609]

Host: Mouse

Reactivity: Human

Specificity: The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Western Blot (WB), Immunohistochemistry (IHC) Paraffin