MBS4381062 | DNA Ligase 1

DNA Ligase 1 | MBS4381062 | Mybiosource

Product Short Name: [DNA Ligase 1]

Product Name Synonyme: [DNA ligase 1; DNA ligase I; DNLI1_HUMAN; LIG 1; lig1; Ligase I DNA ATP dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1]

Other Names: [DNA ligase 1; DNA ligase 1; DNA ligase 1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1]

Product Gene Name: [LIG1]

Product Gene Name Synonyme: N/A

Other Gene Names: [LIG1; LIG1]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [1A9]

Host: Mouse

Reactivity: Human, Mouse, Rat, Bovine

Specificity: DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5' phosphoryl and 3' hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. Furthermore, DNA Ligase I antisense ODNs syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)