MBS4380783 | MerTK (Innate Immune Checkpoint)

MerTK (Innate Immune Checkpoint) | MBS4380783 | Mybiosource

Product Short Name: [MerTK]

Product Name Synonyme: [cEyk; MER receptor tyrosine kinase; MERK; MERPEN; nmf12; Nyk; Proto-oncogene c-Mer; RP38; STK kinase]

Other Names: [tyrosine-protein kinase Mer; Tyrosine-protein kinase Mer; tyrosine-protein kinase Mer; MER proto-oncogene, tyrosine kinase; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK]

Product Gene Name: [MERTK]

Product Gene Name Synonyme: N/A

Other Gene Names: [MERTK; MERTK; MER; RP38; c-Eyk; c-mer; Tyro12; MER]

Clonality: Monoclonal

Isotype: IgG

Clone: [MERTK/3015]

Host: Mouse

Reactivity: Human

Specificity: MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Immunohistochemistry (IHC) Paraffin