MBS4380664 | Calcineurin A/PPP3CA

Calcineurin A/PPP3CA | MBS4380664 | Mybiosource

Product Short Name: [Calcineurin A/PPP3CA]

Product Name Synonyme: [Calcineurin A alpha; Calcineurin A1; Calcineurin A; Calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA1; CAM-PRP catalytic subunit; CCN1; CNA alpha; CNA1; Ppp3ca; Protein phosphatase 2B catalytic subunit (PPP2B); Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform (PPP3CA)]

Other Names: [serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 1; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; protein phosphatase 3 catalytic subunit alpha; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform]

Product Gene Name: [PPP3CA]

Product Gene Name Synonyme: N/A

Other Gene Names: [PPP3CA; PPP3CA; CALN; CCN1; CNA1; CALNA; IECEE; PPP2B; CALNA1; IECEE1]

Clonality: Monoclonal

Isotype: IgG1

Clone: [CALNA/2353]

Host: Mouse

Reactivity: Human. Others not known.

Specificity: Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Immunohistology (Formalin-Fixed)