MBS4380508 | TPO (Thyroid Peroxidase) (Thyroid Marker)

TPO (Thyroid Peroxidase) (Thyroid Marker) | MBS4380508 | Mybiosource

Product Short Name: [TPO (Thyroid Peroxidase)]

Product Name Synonyme: [MSA; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX]

Other Names: [thyroid peroxidase isoform a; Thyroid peroxidase; thyroid peroxidase; thyroid peroxidase]

Product Gene Name: [TPO]

Product Gene Name Synonyme: N/A

Other Gene Names: [TPO; TPO; MSA; TPX; TDH2A; TPO]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [TPO/1922]

Host: Mouse

Reactivity: Human. Others not known.

Specificity: Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: N/A

Tested Application: Immunohistochemistry (IHC) Formalin