MBS4380186 | MAML3 (Mastermind Like Transcriptional Coactivator 3)

MAML3 (Mastermind Like Transcriptional Coactivator 3) | MBS4380186 | Mybiosource

Product Short Name: [MAML3 (Mastermind Like Transcriptional Coactivator 3)]

Product Name Synonyme: [CAGH3; ERDA3; GDN; MAML3; Mastermind-like protein 3; TNRC3]

Other Names: [mastermind-like protein 3; Mastermind-like protein 3; mastermind-like protein 3; mastermind like transcriptional coactivator 3]

Product Gene Name: [MAML3]

Product Gene Name Synonyme: N/A

Other Gene Names: [MAML3; MAML3; GDN; MAM2; CAGH3; ERDA3; MAM-2; TNRC3; mam-3; Mam-3]

Clonality: Monoclonal

Isotype: IgG1

Clone: [MAML3/1303]

Host: Mouse

Reactivity: Human. Others not known.

Specificity: MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jkappa; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin