MBS4380184 | DOG-1/TMEM16A (Gastrointestinal Stromal Tumor Marker)

DOG-1/TMEM16A (Gastrointestinal Stromal Tumor Marker) | MBS4380184 | Mybiosource

Product Short Name: [DOG-1/TMEM16A]

Product Name Synonyme: [Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A]

Other Names: [anoctamin-1; Anoctamin-1; anoctamin-1; anoctamin 1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2]

Product Gene Name: [DOG-1]

Product Gene Name Synonyme: [TMEM16A]

Other Gene Names: [ANO1; ANO1; DOG1; TAOS2; ORAOV2; TMEM16A; DOG1; ORAOV2; TAOS2; TMEM16A]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [rDG1/447]

Host: Mouse

Reactivity: Human. Others not known.

Specificity: Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin