MBS249219 | Mouse Monoclonal [clone 10-12] (IgG1) to Human Complement C4c

Mouse Monoclonal [clone 10-12] (IgG1) to Human Complement C4c | MBS249219 | MyBiosource

Product Short Name: [Complement C4c]

Product Name Synonyme: [Anti-Complement C4c Antibody (clone 10-12) IHC-plus; Complement C4c; Human Complement C4c]

Other Names: N/A

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: N/A

Clonality: Monoclonal

Isotype: IgG1

Clone: [10-12]

Host: Mouse

Reactivity: Human

Specificity: Recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b's alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonization and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kD) and alpha 3 (25 kD) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma. Binds both C4c and C4 and so is not suitable for all ELISA applications.

Purity: Protein A Purified

Form: Borate buffered saline, 0.09% sodium azide

Concentration: 1 mg/ml

Storage Stability: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Tested Application: Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)