MBS245761 | Mouse Monoclonal [clone BED5] (IgG1) to Human TRF1 / TERF1

Mouse Monoclonal [clone BED5] (IgG1) to Human TRF1 / TERF1 | MBS245761 | MyBiosource

Product Short Name: [TRF1 / TERF1]

Product Name Synonyme: [Anti-TRF1 / TERF1 Antibody (clone BED5) IHC-plus; TERF1; HTRF1-AS; NIMA-interacting protein 2; PIN2; Telomeric protein Pin2/TRF1; TRBF1; TTAGGG repeat-binding factor 1; T-TRF1; TRF; TRF1; Human TRF1; TERF1]

Other Names: [telomeric repeat-binding factor 1 isoform 1; Telomeric repeat-binding factor 1; telomeric repeat-binding factor 1; NIMA-interacting protein 2; telomeric protein Pin2/TRF1; TTAGGG repeat-binding factor 1; telomeric repeat binding factor (NIMA-interacting) 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1]

Product Gene Name: [TRF1]

Product Gene Name Synonyme: [TERF1]

Other Gene Names: [TERF1; TERF1; TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS; PIN2; TRBF1; TRF; TRF1]

Clonality: Monoclonal

Isotype: IgG1

Clone: [BED5]

Host: Mouse

Reactivity: Human

Specificity: Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. Reported to work in Western blotting applications.

Purity: Affinity Purified

Form: PBS, pH 7.4, 0.09% sodium azide. Sourced in TCS.

Concentration: 1 mg/ml

Storage Stability: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Tested Application: Immunohistochemistry (IHC - Paraffin; IHC - Frozen), ELISA (EIA)