MBS245411 | Mouse Monoclonal [clone SO1] (IgG2b) to Human SOCS3

Mouse Monoclonal [clone SO1] (IgG2b) to Human SOCS3 | MBS245411 | MyBiosource

Product Short Name: [SOCS3]

Product Name Synonyme: [Anti-SOCS3 Antibody (clone SO1) IHC-plus; SOCS3; Cish3; Cytokine-induced SH2 protein 3; CIS-3; CIS3; SSI-3; STAT-induced STAT inhibitor 3; SSI3; ATOD4; SOCS-3; Human SOCS3]

Other Names: [suppressor of cytokine signaling 3; Suppressor of cytokine signaling 3; suppressor of cytokine signaling 3; STAT-induced STAT inhibitor 3; cytokine-inducible SH2 protein 3; suppressor of cytokine signaling 3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3]

Product Gene Name: [SOCS3]

Product Gene Name Synonyme: N/A

Other Gene Names: [SOCS3; SOCS3; CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3; CIS3; SSI3; SOCS-3; CIS-3; SSI-3]

Clonality: Monoclonal

Isotype: IgG2b

Clone: [SO1]

Host: Mouse

Reactivity: Human

Specificity: Recognizes suppressor of cytokine signaling 3 (SOCS3), a 30kD member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways. SOCS3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. The expression of SOCS3 is inducible by numerous factors, including IL-6, IL-10, Toll-like receptor (TLR) agonists and IFN gamma, making this protein the focus of research into inflammatory diseases, such as Arthritis, Colitis, and Crohn's Disease. SOCS3 expression has also been shown to affect IFN alpha sensitivity in tumor studies.

Purity: Protein A Purified

Form: PBS, pH 7.4, 0.09% sodium azide. Sourced in TCS.

Concentration: 1 mg/ml

Storage Stability: +4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Tested Application: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)