MBS224253 | GOAT ANTI HUMAN MAML1 (N-TERMINAL)

GOAT ANTI HUMAN MAML1 (N-TERMINAL) | MBS224253 | MyBiosource

Product Short Name: [MAML1]

Product Name Synonyme: N/A

Other Names: [mastermind-like protein 1; Mastermind-like protein 1; mastermind-like protein 1; MAML1; mastermind homolog; mastermind-like 1 (Drosophila)]

Product Gene Name: [MAML1]

Product Gene Name Synonyme: N/A

Other Gene Names: [MAML1; MAML1; Mam1; Mam-1; Mam-1]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Goat

Reactivity: Mouse (Expected from Sequence)

Specificity: This item specifically recognises an epitope within the N-Terminal (NT) region of human MAML1 (Mastermind-like Protein 1), a widely expressed nuclear protein and member of the mastermind family, which acts as a crucial coactivator of Notch-mediated transcriptional activation, and plays a role in hematopoietic development, by acting as a regulator of Notch-mediated lymphoid cell fate decisions.

MAML1 interacts with the Mediator complex component CDK8 (Cyclin-dependent kinase 8), enhancing the phosphorylation and proteolytic turnover of the Notch intracellular domain (NICD) within the nucleus, and forms a DNA-binding complex with RBPSUH/RBP-J kappa/CBF1, playing a vital role in the transcriptional activation of Notch targets. Studies have shown that the NT region of MAML1 interacts with the DNA-binding domain of the tumor suppressor protein p53, and that over-expression of MAML1, greatly increases p53-mediated gene transcription and biological function.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 0.5mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: ELISA (EIA), Western Blot (WB)