MBS223075 | RABBIT ANTI HUMAN TOSO (C-TERMINAL)

RABBIT ANTI HUMAN TOSO (C-TERMINAL) | MBS223075 | MyBiosource

Product Short Name: [TOSO ]

Product Name Synonyme: N/A

Other Names: [fas apoptotic inhibitory molecule 3 isoform b; Fas apoptotic inhibitory molecule 3; fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso; Fas apoptotic inhibitory molecule 3; Regulator of Fas-induced apoptosis Toso]

Product Gene Name: [TOSO]

Product Gene Name Synonyme: N/A

Other Gene Names: [FAIM3; FAIM3; FCMR; TOSO; TOSO]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: N/A

Specificity: This item detects an epitope within the C-terminal (CT) region of human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation.

Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS PAGE.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 0.5 mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Western Blot (WB)