MBS222786 | RABBIT ANTI HUMAN PARKIN (pSer378)

RABBIT ANTI HUMAN PARKIN (pSer378) | MBS222786 | MyBiosource

Product Short Name: [PARKIN ]

Product Name Synonyme: N/A

Other Names: [E3 ubiquitin-protein ligase parkin isoform 1; E3 ubiquitin-protein ligase parkin; E3 ubiquitin-protein ligase parkin; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson juvenile disease protein 2; parkinson protein 2, E3 ubiquitin protein ligase (parkin); parkin RBR E3 ubiquitin protein ligase; Parkinson juvenile disease protein 2; Parkinson disease protein 2]

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: [PARK2; PARK2; PDJ; PRKN; AR-JP; LPRS2; PRKN; Parkinson disease protein 2]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: N/A

Specificity: This item specifically recognises the 52kDa parkin protein, when phosphorylated at Ser378.

Parkin is an E3 ubiquitin ligase highly expressed in the brain, which functions in the ubiquitin-proteasome system, together with the E2 ubiquitin conjugating co-enzyme UbcH7. Mutations in the parkin gene are associated with the hereditary neurodegenerative disorder known as autosomal recessive early onset Parkinson disease 2 (PARK2)/autosomal recessive juvenile Parkinson disease (PDJ), characterized by progressive dopaminergic neural cell death. Studies have identified the presence of at least five phosphorylation sites in parkin including Ser378, shown to be phosphorylated by Casein kinase-1 (CK-1), and suggest that phosphorylation of parkin may act to regulate its ubiquitin ligase activity.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: N/A

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.

Tested Application: Western Blot (WB)*