MBS222336 | RABBIT ANTI 14-3-3 ZETA/DELTA

RABBIT ANTI 14-3-3 ZETA/DELTA | MBS222336 | MyBiosource

Product Short Name: [14-3-3 ZETA/DELTA]

Product Name Synonyme: N/A

Other Names: [14-3-3 protein zeta/delta; 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1]

Product Gene Name: [14-3-3 ZETA/DELTA]

Product Gene Name Synonyme: N/A

Other Gene Names: [YWHAZ; KCIP-1]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: Bovine, Chicken, Human, Mammals (Expected from Sequence), Mouse, Rabbit, Rat

Specificity: This item recognizes the acetylated N-terminal of 14-3-3 zeta and the phosphorylated zeta isoform (also known as 14-3-3 delta) in all mammals. These are members of the 14-3-3 family which consists of 30kDa proteins that are involved in multiple protein kinase signaling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 zeta is a susceptibility gene for paranoid schizophrenia and is overexpressed in the temporal cortex of cognitively impared Alzheimers patients. The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. It co-localizes with epidermal growth factor receptor to the plasma membrane following epidermal growth factor signaling. The zeta isoform is involved in MAPKAPK2-mediated phosphorylation which may have a role in p38 MAPK-dependent inflammation. When bound to ADAM 22, 14-3-3 zeta is involved in cell adhesion. 14-3-3 zeta also interacts with cofilin, LIM-domain-containing protein kinase 1, protein kinase B/Akt and GPI alpha. 14-3-3 zeta can be phosphorylated at serine 184 to produce 14-3-3 delta.This item may not react with recombinant proteins that are not N-acetylated.

Purity: N/A

Form: Serum
Serum - liquid

Concentration: N/A

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)