MBS222332 | RABBIT ANTI 14-3-3 GAMMA

RABBIT ANTI 14-3-3 GAMMA | MBS222332 | MyBiosource

Product Short Name: [14-3-3 GAMMA]

Product Name Synonyme: N/A

Other Names: [14-3-3 protein gamma; 14-3-3 protein gamma; Protein kinase C inhibitor protein 1; KCIP-1]

Product Gene Name: [14-3-3 GAMMA]

Product Gene Name Synonyme: N/A

Other Gene Names: [YWHAG; KCIP-1]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: Bovine, Chicken, Human, Mammals (Expected from Sequence), Mouse, Rat

Specificity: This item recognises the acetylated N-terminal of 14-3-3 gamma. It is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for it's different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein.

14-3-3 gamma is thought to play an important role in muscle, being induced by growth factors in human vascular smooth muscle cells, and being expressed in skeletal and heart muscles. An example is the gamma isoform binds muscle-specific receptor tyrosine kinase regulating synaptic gene transmission.

The gamma isoform binds amyloid beta-protein precursor intracellular domain fragment (AICD) and FE65, facilitating FE65-dependent gene transactivation. The binding of 14-3-3 gamma to glial fibrillary acidic protein is important in the regulation of glial filaments. 14-3-3 gamma binds and may regulate CDK11 during the cell cycle and apoptosis. The gamma isoform is lowered in foetal Downs syndrome brains.

Purity: N/A

Form: Serum
Serum - liquid

Concentration: N/A

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)