MBS221872 | RABBIT ANTI HUMAN APOBEC3G (N-TERMINAL)

RABBIT ANTI HUMAN APOBEC3G (N-TERMINAL) | MBS221872 | MyBiosource

Product Short Name: [APOBEC3G ]

Product Name Synonyme: N/A

Other Names: [DNA dC->dU-editing enzyme APOBEC-3G; DNA dC->dU-editing enzyme APOBEC-3G; DNA dC->dU-editing enzyme APOBEC-3G; APOBEC-related cytidine deaminase; APOBEC-related protein 9; DNA dC->dU editing enzyme; apolipoprotein B editing enzyme catalytic polypeptide-like 3G; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G; deoxycytidine deaminase; phorbolin-like protein MDS019; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; APOBEC-related cytidine deaminase; APOBEC-related protein; ARCD; APOBEC-related protein 9; ARP-9; CEM-15; CEM15; Deoxycytidine deaminase; A3G]

Product Gene Name: [APOBEC3G]

Product Gene Name Synonyme: N/A

Other Gene Names: [APOBEC3G; APOBEC3G; A3G; ARCD; ARP9; ARP-9; CEM15; CEM-15; MDS019; bK150C2.7; dJ494G10.1; APOBEC-related protein; ARCD; ARP-9; CEM15; A3G]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: N/A

Specificity: This item recognises an epitope within the N-terminal region (NT) of APOBEC3G (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G), a 46kDa multi-isoform endogenous deoxycytidine deaminase, which plays a major role in the defence of T lymphocytes against retroviral infection.

The incorporation of APOBEC3G into HIV-1 virion DNA, results in the deamination of dC to dU in minus-strand viral DNA during reverse transcription, thereby generating G to A hypermutations in the newly-synthesised viral DNA. The effect of APOBEC3G is counteracted by the HIV protein Vif, thought to induce the degradation of APOBEC3G through a ubiquitin-dependant proteasomal pathway.

This item also detects the APOBEC3F isoform (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3F).

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunohistology Paraffin*, Western Blot (WB)