MBS221460 | RABBIT ANTI BAG1 (N-TERMINAL)

RABBIT ANTI BAG1 (N-TERMINAL) | MBS221460 | MyBiosource

Product Short Name: [BAG1 ]

Product Name Synonyme: N/A

Other Names: [BAG family molecular chaperone regulator 1 isoform BAG-1S; BAG family molecular chaperone regulator 1; BAG family molecular chaperone regulator 1; Bcl-2 associating athanogene-1 protein; Bcl-2-binding protein; glucocortoid receptor-associated protein RAP46; receptor-associated protein, 46-KD; BCL2-associated athanogene; Bcl-2-associated athanogene 1]

Product Gene Name: [BAG1]

Product Gene Name Synonyme: N/A

Other Gene Names: [BAG1; BAG1; HAP; BAG-1; RAP46; HAP; BAG-1]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: Mouse

Specificity: This item detects an epitope within the N-terminal (NT) region of Bcl-2 associated athanogene-1 (BAG1), a co-chaperone protein which binds to and regulates the 70kD heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival.

The BAG1 gene encodes three different isoforms; a predominantly cytosolic form of 36kD (BAG1S), a 46kD cytosolic and nuclear form (BAG1M), and a predominantly nuclear form 50kD (BAG1L).

BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Western Blot (WB)