MBS221323 | RABBIT ANTI HUMAN NOD2 (C-TERMINAL)

RABBIT ANTI HUMAN NOD2 (C-TERMINAL) | MBS221323 | MyBiosource

Product Short Name: [NOD2 ]

Product Name Synonyme: N/A

Other Names: [nucleotide-binding oligomerization domain-containing protein 2 isoform 2; Nucleotide-binding oligomerization domain-containing protein 2; nucleotide-binding oligomerization domain-containing protein 2; NLR family, CARD domain containing 2; NOD-like receptor C2; caspase recruitment domain family, member 15; caspase recruitment domain protein 15; caspase recruitment domain-containing protein 15; inflammatory bowel disease protein 1; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; nucleotide-binding oligomerization domain containing 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1]

Product Gene Name: [NOD2]

Product Gene Name Synonyme: N/A

Other Gene Names: [NOD2; NOD2; CD; ACUG; BLAU; IBD1; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1; CARD15; IBD1]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: N/A

Specificity: This item recognises NOD2, an intracellular protein of 100kDa, which belongs to the NOD (nucleotide binding oligomerisation domain) family. The NOD family comprises at present more than 20 different mammalian NOD-LRR (leucine-rich repeat) proteins, which are involved in the regulation of apoptosis and the immune response.

NOD2 has been shown to be constitutively or inducibly expressed in monocytes, macrophages, T and B cells, dendritic cells, as well as intestinal epithelial cells. A specific motif of peptidoglycan (PGN), muramyl dipeptide (MDP), has been identified as the sole ligand of NOD2.

NOD2 and Toll-like receptors (TLR) are emerging as key mediators of innate host defence in the intestinal mucosa, crucially involved in maintaining mucosal and commensal homeostasis.

Mutations in the gene encoding NOD2 are a major susceptibility factor underlying a significant subgroup of patients with Crohn's disease.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 0.5mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunohistology Frozen, Western Blot (WB)