MBS214428 | MOUSE ANTI HUMAN BUB1

MOUSE ANTI HUMAN BUB1 | MBS214428 | MyBiosource

Product Short Name: [BUB1]

Product Name Synonyme: N/A

Other Names: [mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 3; Mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase; BUB1 mitotic checkpoint serine/threonine kinase; BUB1A]

Product Gene Name: [BUB1]

Product Gene Name Synonyme: N/A

Other Gene Names: [BUB1; BUB1; BUB1A; BUB1L; hBUB1; BUB1L; hBUB1]

Clonality: Monoclonal

Isotype: IgG1

Clone: [14H5]

Host: Mouse

Reactivity: N/A

Specificity: This item detects Bub1, a protein kinase involved in spindle checkpoint function during mitosis. Bub1 co-operates with Aurora B kinase to inhibit Cdc20-mediated activation of the anaphase promoting complex/cyclosome (APC/C) until all the chromosomes correctly align on the microtubule spindle apparatus via their kinetochores, thus ensuring high fidelity mitotic chromosome segregation.

Bub1 is also required for assembly of a functional inner centromere, sister chromatid cohesion via targeting of the Shugoshin protein, and metaphase congression.

Mutation or aberrant Bub1 expression is associated with chromosomal instability, aneuploidy, and human cancer.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunofluorescence (IF)*, Immunoprecipitation (IP), Western Blot (WB)