MBS214228 | HAMSTER ANTI NOTCH 1

HAMSTER ANTI NOTCH 1 | MBS214228 | MyBiosource

Product Short Name: [NOTCH 1]

Product Name Synonyme: N/A

Other Names: [neurogenic locus notch homolog protein 1; Neurogenic locus notch homolog protein 1; neurogenic locus notch homolog protein 1; Motch A; Notch gene homolog 1; mT14; major type A protein; p300; transmembrane receptor Notch1; notch 1; Motch A; mT14; p300Cleaved into the following 2 chains:Notch 1 extracellular truncation; NEXT; Notch 1 intracellular domain; NICD]

Product Gene Name: [NOTCH 1]

Product Gene Name Synonyme: N/A

Other Gene Names: [Notch1; Notch1; N1; Mis6; Tan1; lin-12; 9930111A19Rik; Motch; Notch 1; NEXT; NICD]

Clonality: Monoclonal

Isotype: IgG1

Clone: [8G10]

Host: Hamster

Reactivity: Rat

Specificity: This item specifically recognises Notch 1, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands.

The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression.

Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation.

Notch 1 is expressed in a range of cells including haematopoietic cells in mouse foetal liver, adult thymus and bone marrow. Notch 1 signalling plays a role in follicular differentiation, tissue homeostasis, and in both CD4+ and CD8+ cell maturation in the thymus. Studies have also implicated Notch 1 in the regulation of lymphopoieisis, myelopoiesis, and neurogenesis.

Purity: N/A

Form: Tissue Culture Supernatant - liquid

Concentration: N/A

Storage Stability: Store at -20 degree C only (ship 4 degree C). Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunohistology Frozen, Flow cytometry (FC/FACS), Western Blot (WB)