MBS212936 | MOUSE ANTI HUMAN C8

MOUSE ANTI HUMAN C8 | MBS212936 | MyBiosource

Product Short Name: [C8]

Product Name Synonyme: N/A

Other Names: [complement component C8 beta chain preproprotein; Complement component C8 beta chain; complement component C8 beta chain; complement component 8 subunit beta; complement component 8, beta polypeptide; Complement component 8 subunit beta]

Product Gene Name: [C8]

Product Gene Name Synonyme: N/A

Other Gene Names: [C8B; C8B; C82]

Clonality: Monoclonal

Isotype: IgG1

Clone: [056B-373]

Host: Mouse

Reactivity: N/A

Specificity: This item recognises complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane.

Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Western Blot (WB)