MBS212714 | MOUSE ANTI HUMAN CD195 (NON-PHOSPHORYLATED)

MOUSE ANTI HUMAN CD195 (NON-PHOSPHORYLATED) | MBS212714 | MyBiosource

Product Short Name: [CD195 ]

Product Name Synonyme: N/A

Other Names: [C-C chemokine receptor type 5; C-C chemokine receptor type 5; C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; HIV-1 fusion coreceptor; chemokine receptor CCR5; chemr13; chemokine (C-C motif) receptor 5 (gene/pseudogene); CHEMR13; HIV-1 fusion coreceptor; CD_antigen: CD195]

Product Gene Name: [CD195]

Product Gene Name Synonyme: N/A

Other Gene Names: [CCR5; CCR5; CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; CMKBR5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5]

Clonality: Monoclonal

Isotype: IgG1

Clone: [R-C10]

Host: Mouse

Reactivity: N/A

Specificity: This item is specific for human CD195, a cell surface antigen of approximately 40kD, also known as CCR5. This antibody has been shown to exclusively recognise CD195 which is non-phosphorylated at Ser337, see Pollok-Kopp, B.et al. for details. Human CD195 is a member of the G protein coupled superfamily of receptors, which acts as a receptor for a number of chemokines including RANTES and also serves as a co-receptor for the entry of HIV into cells. It plays a key role in regulating the activation and migration of leukocytes. CD195 is expressed by a subset of T lymphocytes and by monocytes. CD195 is rapidly phosphorylated within the C-terminal domain upon ligand stimulation. Recent studies suggest that phosphorylation at Ser337 is mediated by Protein kinase C, whereas phosphorylation at Ser349 is mediated by GPCR kinases, see Pollok-Kopp, B.et al. for details. Clone R-C10 has not yet been tested for reactivity with human CD195 phosphorylated at other residues.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0 mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)