L-valine

Valine: Essential Amino Acid with Critical Biological Significance

Valine, an α-amino acid denoted by the IUPAC-IUBMB abbreviation Val and incorporated as one of the 22 proteinogenic amino acids, holds a prominent position among the nine amino acids deemed essential for human health. Its distinctive features include an apolar isopropyl group, rendering it crucial for various physiological functions and metabolic pathways.

The etymology of its name stems from its identification in the valerian plant, reflecting its natural occurrence and widespread distribution. The molecular structure of valine showcases a lateral chain characterized by a branched and symmetric aliphatic nature, contributing significantly to its functional versatility within the cellular environment.

Encoded on mRNA by the GUU, GUC, GUA, and GUG codons, valine plays a crucial role in the regulation of essential biological processes, including muscle metabolism, tissue repair, and overall growth. Its involvement in protein synthesis, energy production, and the maintenance of nitrogen balance underscores its indispensable role in sustaining optimal human health and well-being.

Furthermore, recent research has highlighted the intricate role of valine in the context of various metabolic disorders, emphasizing its significance as a potential therapeutic target for the management of specific health conditions. Ongoing investigations continue to illuminate the multifaceted contributions of valine, reinforcing its status as a pivotal component in the realm of human physiology and biochemistry.

MBS358066 | Polyclonal anti-conjugated L-valine antibodies
MBS358322 | L-Valine (BSA) conjugate
MBS405130 | L-Valine
MBS545406 | L-VALINE
MBS611223 | L-Valine, Conjugated
MBS651371 | Enniatin A1 (2-(N-Methyl-L-valine) Enniatin A)
MBS653430 | MEM Eagle D-Valine Modification w/L-Glutamine, D-Valine (Powder)
MBS6016418 | L-Valine
MBS6021600 | N-Boc-L-valine-O-nitrophenyl Ester
MBS6024215 | L-Valine (non-animal)
MBS6045797 | L-Valine N-Carboxyanhydride
MBS6052292 | N-(2-Cyanoethyl)-L-valine
MBS6054891 | N-(3-Propanamido)-L-valine tert-Butyl Ester
MBS6063116 | N-Phenoxycarbonyl-L-valine
MBS6095045 | L-Valine Benzyl Ester Hydrochloride
MBS6103210 | L-Valine-d8
MBS3609030 | L-Valine
MBS3611393 | Glycyl-L-valine
MBS4158173 | Anti-Conjugated L-Valine Antibody
MBS5750180 | L-Valine


Accession Number : KLM0000406 This work is released into the public domain; please see our release statement.

l-valine-3d.gif

Synonyms :

 

  • L-VALINE
  • Val
  • V

 

Config Rule :

 

config('L-valine',[
        substituent(aminoacid_L_backbone),
        substituent('propa-beta-yl'),
        linkage(from(aminoacid_L_backbone,car(1)),
                to('propa-beta-yl',car(1)),
                down,single)]).

%%%% Substituent Config Rules for compound 'L-valine' %%%%

config(aminoacid_L_backbone,[
        left(amino),
        right(hyd),
        top(carboxyl),
        center(car(1))]).

config('propa-beta-yl',[
        center(car(1)),
        left(methyl),
        right(hyd),
        bottom(methyl)]).

Smiles String :

 

[C@2H]([NH3+])([C](=[O])[O-])[C@2H]([CH3])[CH3]

'L-valine'

Fischer Diagram :

 

Terminal :

% 'L-valine'

c(1,12,(0,chiral))-[n(1,left)~,h(1,right)~,c(2,up)~,c(3,down)~],
c(2,12,(0,nonchiral))-[o(1,nil)?,o(2,nil)?,c(1,down)~],
c(3,12,(0,nonchiral))-[c(4,left)~,h(5,right)~,c(1,up)~,c(5,down)~],
c(4,12,(0,nonchiral))-[h(6,left)~,c(3,right)~,h(7,up)~,h(8,down)~],
c(5,12,(0,nonchiral))-[h(9,left)~,h(11,right)~,c(3,up)~,h(10,down)~],
h(1,1,(0,nonchiral))-[c(1,left)~],
h(2,1,(0,nonchiral))-[n(1,right)~],
h(3,1,(0,nonchiral))-[n(1,down)~],
h(4,1,(0,nonchiral))-[n(1,up)~],
h(5,1,(0,nonchiral))-[c(3,left)~],
h(6,1,(0,nonchiral))-[c(4,right)~],
h(7,1,(0,nonchiral))-[c(4,down)~],
h(8,1,(0,nonchiral))-[c(4,up)~],
h(9,1,(0,nonchiral))-[c(5,right)~],
h(10,1,(0,nonchiral))-[c(5,up)~],
h(11,1,(0,nonchiral))-[c(5,left)~],
n(1,14,(1,nonchiral))-[h(2,left)~,c(1,right)~,h(3,up)~,h(4,down)~],
o(1,16,(-5.0E-01,nonchiral))-[c(2,nil)?],
o(2,16,(-5.0E-01,nonchiral))-[c(2,nil)?]

The Terminals for all the Config Rules are in Prolog Definite Clause Grammar (DCG) form.They can be checked in the Manual here.

The compound's PDB file can be seen here.