MBS4381247 | VISTA/GI24 (Negative Regulator of Immune Response)

VISTA/GI24 (Negative Regulator of Immune Response) | MBS4381247 | Mybiosource

Product Short Name: [VISTA/GI24]

Product Name Synonyme: [B7H5; DD1alpha; GI24; PD-1H; PDCD1 homolog; Platelet receptor Gi24; PP2135; Stress-induced secreted protein 1 (SISP1); V domain Ig suppressor of T cell activation; V Set Immuno-regulatory Receptor]

Other Names: [V-type immunoglobulin domain-containing suppressor of T-cell activation; V-type immunoglobulin domain-containing suppressor of T-cell activation; V-type immunoglobulin domain-containing suppressor of T-cell activation; V-set immunoregulatory receptor; Platelet receptor Gi24]

Product Gene Name: [VISTA/GI24]

Product Gene Name Synonyme: [VSIR]

Other Gene Names: [VSIR; C10orf54; B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha; ; Sisp-1]

Clonality: Monoclonal

Isotype: IgG2b, kappa

Clone: [VISTA/3006]

Host: Mouse

Reactivity: Human

Specificity: VISTA/GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30kDa extracellular fragment plus a 25-30kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment). It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: ELISA (EIA), Immunohistochemistry (IHC) Paraffin